T-cell activation is absolutely crucial for proper immune function. Many people who suffer from immune deficiencies (namely those with HIV/AIDS among others) are in a constant battle to support healthy T cell count and one method of doing so is by supporting the dendritic cells.
Dendritic cells work to help with T-cell activation by maturing and creating a successful first step in the T cell activation process. Without this step being completed the next step in activation T-cells could not be completed. These cells actually stimulate the T-cell receptor by the major histocompatibility complex peptide, thereby allowing the next step in the process to occur.
Maturation of Dendritic Cells
The rest of the process is far more complex but relies on this step being accomplished. When dendritic cells are not matured they do not support the process of T-cell activation and do not allow for the second step to make a difference.
T Cell Activation
The second step of the T-cell activation process has to do with the activation of the CD28 molecule which is the other side of the process in activating T cells. This molecule requires the B7 protein to stimulate it however the blockage of this protein is a concern. If the B7 protein can stimulate the CD28 molecule while the dendritic cell stimulates the major histocompatibility complex peptide then the T-cell can activate and the immune system can be supported.
Anyone schooled in this area cal tell you that the trick is in the stimulation of the B7 protein and those who suffer from immune problems are likely to have trouble in this area. This is why it is absolutely important to make sure and control the area of science we firmly have a grip on. Dendritic cells help with T-cell activation and help increase T cell count and as long as we can keep them mature and under control we can set ourselves up for the best possible outcome in the second step in the activation process and with luck we can support our healthy immune systems more so than before.