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Is There a Link Between Autoimmune Disease and Vitamin B12 Deficiency?

By Edited Nov 20, 2016 2 6
Autoimmune Disease List
Credit: Hollster

Autoimmune Disease Rates are on the Rise

It’s no secret that there seems to be an increase in the number of people who suffer from autoimmune disorders, such as: Type I Diabetes; Hashimoto’s thyroiditis; Grave’s Disease;  Diverticulitis; Inflammatory Bowel Disease; Scleroderma;  Multiple Sclerosis; Rheumatoid Arthritis; Allergic Reactions; Psoriasis; Celiac Disease; Fibromyalgia; and Systemic Lupus Erythematosus (SLE) (please don’t be offended if I’ve left your disease out of the list; there are more than 80 known autoimmune diseases, so we’d be here all day). Our immune systems are failing to attack the real enemies. Our immune systems must obviously be confused if they are mistaking our own body parts, or systems, as the enemy, but why are they doing this?

  • Is it what we eat (GMO, non-organic, and processed food)?
  • Is it our toxic environment?
  • Were we given too many vaccines for our bodies to process at once?
  • Is it our prescription medications?
  • Is there a virus or bacteria we haven’t yet discovered?
  • Is it just a matter of survival of the fittest and we’re supposed to just suffer and die out (but we keep procreating and making more children with hyperactive autoimmune systems)?
  • Is it because my grandmother and her sisters sat on top of their roofs as teens to watch the Nevada nuclear bomb testing in the 1950’s because they thought it was cool to see their bones through their skin?
  • Is our God just punishing us as a whole for being heathens?
Opening Prescription Bottle
Credit: Hollster

Is Masking Our Symptoms Making Hurting Our Health?

No one really knows exactly what triggers our immune systems to shift into hyper-drive when it mistakes a friend for an enemy…maybe our body’s natural defense mechanism is evolving to fight the 2nd leading cause of death, cancer (this includes all cancer types)[1], so that we will survive as a species. Who knows? 

While exact causes of autoimmune diseases are unknown, we are treated with drugs to suppress or mask our symptoms so we can function day-to-day. It seems to me that treating one problem with a drug typically results in another problem. For example, a friend of mine had 3 close family members that were prescribed an immunosuppressive drug to treat the same autoimmune disease in each person; while no one in that family was ever known to have had cancer before, each person consequently died of cancer in a relatively short period of time after starting the immune system suppressing drugs. While I realize that some of my examples in this article are purely anecdotal, I’ve read that a well-functioning immune system is designed to recognize and kill cancer cells before they become a problem. Are we allowing cancer cells to blossom when we suppress our immune systems? 

Why Should We Care About Autoimmune Diseases as Whole Society?

If you’re an autoimmune disease sufferer, I’m sure you’ve also read countless, differing theories for why our immune systems are going haywire. In my family, 6 close family members over 3 generations have been diagnosed with the same autoimmune disease…so, naturally, we’re all told that genetics is partly or wholly to blame. While this appears to be the case, I refuse to accept it because I want to know what we’re doing as a society to cause our genes to mutate like this so we can stop doing it before we have a future society of mutants living in excruciating pain or before we have no future at all. This isn’t a little problem. This is a big problem that is slowly creeping in and taking over our bodies. In 2005, the National Institutes of Health’s Autoimmune Diseases Coordinating Committee reported to the U.S. Congress that “[w]hile many of these [autoimmune] diseases are rare, collectively they affect 14.7 to 23.5 million (5 to 8 percent) people in this country, and – for reasons unknown – their prevalence is rising”[2]

The American Autoimmune Related Diseases Association estimates that about 50 million (1 in 5) Americans suffer from autoimmune diseases because their statistics include 80 or more autoimmune diseases while the National Institutes of Health include only 24 autoimmune diseases[3]; so either more autoimmune diseases are being discovered or more people are being diagnosed with them. Regardless of the reason, the autoimmune disease authorities agree that numbers are rising and that the medical community needs to pay closer attention to this fact.

I propose that we look at this issue as a whole autoimmune disease issue; not to focus only on the small subset diseases. I think that we possibly aren’t seeing the forest for the trees, in this case. While we have walk-a-thons and other fundraising events to raise awareness and to help find cures for very specific autoimmune disease subset, many people have more than one autoimmune disease at a time. I believe there’s probably a common root cause that’s bigger than just our immune systems choosing which parts of our bodies to focus their attacks on. Maybe our immune systems are lacking something very important in order to function properly.

MTHFR Genotype Test Result
Credit: Hollster

What If the Solution is Just That Simple?

Here’s another little anecdote that I’ll share with you that caused a light bulb to switch on in my brain: someone close to me experienced hair loss in strange places, was substantially underweight, and had low thyroid function results, which did not make sense because a person with a low functioning thyroid would typically be overweight; Grave’s disease was suspected by the doctor and Hashimoto’s thyroiditis is highly prevalent in this person’s family. Further testing showed a Vitamin B12 deficiency. Even more testing revealed that this young person has a gene mutation (Heterozygous A1298C Mutation); this mutation prevents the body’s cells from absorbing Vitamin B12. A simple enzyme supplement and larger doses of B12 helped the hair to grow back and this person began to gain weight. New thyroid labs are still pending.  Now, I am not a medical professional or a scientist…just a health-enthusiast geek who likes to read medical journals and studies just for fun once in awhile. Like many of you, I’m just a person who is searching for answers. Why are we so sick, as a society?

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I’d like to pose a few questions for all of us to ponder…just to stimulate conversation about autoimmune diseases as a whole entity and to think about possible root causes:

  1. Is there a correlation between a thyroid autoimmune disease and lack of B12?
  2. Could the lack of B12 actually cause damage to the immune system over a long period of time?
  3. Furthermore, is there a strong correlation between all autoimmune diseases and a lack of Vitamin B12? 
Idea Light Bulb
Credit: Hollster

I began to wonder how common this B12-limiting Heterozygous A1298C Mutation is and many people might have it. I wasn’t able to find a clear number for how many people specifically have the Heterozygous A1298C Mutation, but, according to GB HealthWatch, if we include the other most common genetic mutation that limits B12 absorption, C677T Mutation, it is estimated that anywhere from 13% to 57% worldwide, depending on which ethnic group, carries one of these genetic variants[4]. Furthermore, I began to wonder how many people in our United States, in general, have a B12 deficiency. According to McBride of the United States Department of Agriculture (USDA), a study revealed that 39% of the tested subjects showed a less than ideal level of B12 in them[5]

Now, that is a lot of people! Symptoms of a B12 deficiency may be so subtle and increase so gradually over time that we may not notice them for many years. B12 deficiencies can be attributed to multiple causes, such as: a genetic mutation that limits, or prevents, absorption; a diet that lacks B12; or medications that interfere with B12 absorption.

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As newer studies are gradually revealing a significant connection between certain autoimmune diseases and a Vitamin B deficiency[6], maybe this will mean that it’s within our grasp to prevent further progression of lifelong immune disorders by simply finding out if we have a Vitamin B deficiency and what the cause of it might be. It also wouldn’t hurt to eat whole, raw non-GMO and organic fruits and vegetables and to limit our consumption of processed foods (cooking and reheating food causes about half of the B12 to be destroyed[7]).

While I hate to subscribe to a modern-day, hippie-type label (I don’t really like labels, in general), my ‘ah-ha’ moment that made me wonder if there is a correlation between autoimmune diseases and B12 deficiency caused me to re-think the way I live my life a little more. Maybe I’ll use more natural, less toxic cleaning solutions, shampoos, and body washes. Maybe I’ll try to eat more fresh vegetables and fruits. I hope you do too.

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Oct 14, 2015 7:55am
Interesting. The more I read, the more I am convinced that 90 percent of today's ailments are a result of a diet of highly processed, nutrient poor food.
Oct 15, 2015 5:40pm
Thanks, H. Lesley! I agree. I can't decide if our ailments are related to environment; vitamin deficiencies; too many vaccines at the same time; a combo of small-dose radiation emissions from our laptops, smart phones, tablets; processed food; or a combination of all of the above. I love that we have the environment to share and stimulate thoughts in!
Oct 14, 2015 7:55am
Interesting. The more I read, the more I am convinced that 90 percent of today's ailments are a result of a diet of highly processed, nutrient poor food.
Nov 6, 2015 3:52am
Excellent article - a down to earth and thought provoking approach. There is no No 1 cause. We can't help our genes, but we can eat so as not to provoke them! Gluten is a major culprit and so is the mercury in our mouths. But we all need more B12! I believe that parasites like roundworms also consume a lot of the little we have. I need to investigate.
Nov 27, 2015 10:45pm
Thank you! Yes, I think there are multiple factors too. While writing the article, there were so many tangents I want to travel down...it was hard to focus on one small thing. I'm forever a student, always wanting to learn more about everything...always searching for answers. I agree we have parasite probs in the U.S. too. Some of the doctor I've asked to test me in the past said they don't exist here (ha ha ha), like there's a magic shield that separates parasites from coming into our country from all of the other bordering countries...when did Western medicine move so far away from common sense?
Dec 7, 2015 12:16am
The plot thickens. I found a link to the brain pathway for B12. Evidently it needs Lithium to be transported into the brain. (That doesn't help much, because a lot of people are on lithium but don't have the B12.) Evidently there used to be enough lithium in our drinking water but we filtered out all the other muck and so some people have serious lithium deficiencies. We are a funny bunch!
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  1. "Top 10 leading causes of death." Medical News Today. 7/09/2015. 10/09/2015 <Web >
  2. National Institutes of Health THE AUTOIMMUNE DISEASES COORDINATING COMMITTEE "Progress in Autoimmune Diseases Research." National Institutes of Health. 10/09/2015 <Web >
  3. America "Autoimmune Information: Questions and Answers." American Autoimmune Related Diseases Association, Inc.. 10/09/2015 <Web >
  4. "Cardiovascular diseases and the MTHFR gene ." GB HealthWatch. 10/09/2015 <Web >
  5. Judy McBride "B12 Deficiency May Be More Widespread Than Thought." United States Department of Agriculture - Agricultural Research Service. 2/08/2000. 10/09/2015 <Web >
  6. Janet Renee "B12 Deficiency and Autoimmune Disorders." Livestrong.com. 16/08/2013. 10/09/2015 <Web >
  7. SELF Magazine "Nutritional Effects of Food Processing." SELFNutritionData: know what you eat. 10/09/2015 <Web >

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