A Collection of Expert Quotes to Show Your Lawyer

Let's Not Normalize These Rare Cancers in Young People

Enucleated eyeball and chemo equipment
Credit: Eyeball image: Simone Trovato Monastra (CC BY-SA 4.0) | Chemo image: David Beach on flickr (CC-by-2.0)

I Connected the Dots By Following the Science

Some studies are under paywalls, so I posted key points:

A 2011 paper by Judith A. Ferry states:

"Primary uveal tract lymphoma is typically a low-grade B-cell lymphoma ... involvement is usually unilateral, but occasionally both eyes are involved ... Enucleation [surgical removal] of the eye occasionally [often?] has been performed because of a clinical impression of uveal melanoma ..."[1]

Non-Hodgkin's lymphoma, diffuse large B-cell type (the most common type of non-Hodgkin's lymphoma), is the type identified in this 2015 publication by Chen, Dong, et al: Detection of Wolbachia genes in a patient with non-Hodgkin's lymphoma.[2]

Should Be Making the Rounds in Every Oncology Department 

Chen, Dong, et al. clearly state:

1) The findings suggest the potential for Wolbachia bacteria to infect humans.

2) The 16S rRNA and fbpA gene sequences amplified from the patient's blood on days 0 and 4 were identical and clustered with those of supergroup B members of the genus Wolbachia.

Fact: Supergroup B includes Wolbachia pipientis, the type MosquitoMate is using in 20 U.S. states (see screenshot further along).

3) After Wolbachia genes were detected, levofloxacin was administered for one week. Over the next seven days, his temperature gradually returned to normal.

During that week, jaundice increased and pancytopenia gradually developed. Bone marrow aspirate revealed 10% large atypical cells with haemophagocytosis that was diagnosed as non-Hodgkin's lymphoma, diffuse large B-cell type (aka DLBCL or DLBL).

4) The patient was transferred to the Haematology Department for three cycles of R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone).

Incredibly, a follow-up bone marrow aspirate and flow cytometry two weeks later showed no malignant cells.

PET-CT (positron emission tomography–computed tomography) revealed no residual tumour, and the patient's pancytopenia and liver function abnormalities resolved.

5) The patient was then considered to have had a complete remission. No Wolbachia genes were amplified from blood obtained at the patient's hospital discharge.

Worth repeating: The patient was then considered to have had a complete remission.

The Connection to Uveal Melanoma?

Sometimes diffuse large B-cell lymphoma (DLBCL or DLBL) develops in people who have had a low-grade (slow-growing) lymphoma in the past[3] [which would include primary uveal tract lymphoma].

And as you look through study literature, you will find many "unknowns" and "poorly understood" factors.

Why is the Scientific/Medical Community Ignoring This?

Arthropods can be co-infected with distinct Wolbachia strains:

GenBank sequences of 16S rRNA (A) and fbpA (B) genes of Wolbachia and Chen, Dong, et al. study patient
Credit: Partial Screenshots of Fig. 1 (Red outlines added by RoseWrites) | Detection of Wolbachia genes in a patient with non-Hodgkin's lymphoma [Fair Use]

EPA Quietly Approved 20 States and MosquitoMate is

Seeking Nationwide Releases. Even Oxitec Ltd. Complained.

MosquitoMate Allowed to Release Wolbachia-Infected Aedes in 20 U.S. States and Wants Nationwide Releases
Credit: Screenshot and snippets by Rose Webster [Fair Use]

Wolbachia Pipientis Could Introduce Over 1000 New Genes

When mosquitoes, eggs, and larvae die, something else acquires it.

Oxitec Ltd. Complained About Wolbachia Pipientis by MosquitoMate
Credit: Rose Webster [Fair Use]

In 2016, the EPA Approved Four (Not Two) States | In red are the 20 U.S. States Approved November 2017

I knew about California and Florida; not Kentucky and New York:

Where Wolbachia-Infected Aedes Were Released in 2016
Credit: Rose Webster (aka RoseWrites)

Dark Blue Depicts Most (Not All) Standing Bodies of Water

Nighttime-active Culex spp. prefer ponds, lakes, and marshes:

Culex spp. prefer open, standing bodies of water, shown on U.S. public domain map
Credit: Map: Public Domain | Dark Blue Color: by RoseWrites (to show standing bodies of water)

Quezon City has the most homeless souls in the world

This supports overnight-active Culex spp. as a vector of Zika:

Top 20 Organic Visits to Zika Symptoms in Men Page by RoseWrites Feb. 1, 2018
Credit: Rose Webster (aka RoseWrites on InfoBarrel) | Ask me about reuse.

Orlando, FLA was #27 on my list of the top 30 visitors

Is that why they are releasing even more in Florida?

Jan. 30, 2018 More Wolbachia-Infected Aedes to be Released in Miami
Credit: Rose Webster [Fair Use]

You might as well sprinkle Wolbachia over everything

because even dead mosquitoes, eggs, and larvae pose a risk:

The presence of a virus facilitates the invasion of Wolbachia (Strauß and Telschow, 2015)

Some Scientists Clearly See the Imminent Dangers

Yet the EPA trashed half of their key board's scientific advisers.

Dr. Steve Slater's Public Comment Regarding Wolbachia-Infected Mosquitoes
Credit: Rose Webster [Fair Use; Public Comment Posted]

A Quick Google Search Revealed the Following

Even some governments are disseminating FALSE information:

Google Search Page 1 False Info About Wolbachia Even by Govts
Credit: Rose Webster (aka RoseWrites) Google Search, Page 1 Results on Feb. 8th, 2018

Since 2006, it's been known that Wolbachia CAN survive

outside host cells for (at least) a week with no decrease in viability:

Survival of Wolbachia pipientis in Cell-Free Medium by Jason L. Rasgon, Courtney E. Gamston, and Xiaoxia Ren
Credit: Screenshot and snippets [Fair Use]

The Huntersville Cluster of Uveal Melanoma Cases

Then the Auburn, Alabama cluster (there will be more):

Karen Dobson went to North Carolina State University. She is the overall manager for Mass Rearing Operations of MosquitoMate; Stephen Dobson is the CEO of MosquitoMate.[4]
 
North Carolina State University is only 2 hours and 21 mins (160.3 miles / 268 km) away from Huntersville, North Carolina.
 
Of course, mosquitoes get transported to neighboring states rather easily via cargo, shipping containers, and vehicles. And mosquitoes, larvae and eggs will all contain Wolbachia. Rain, wind, and waterways also transport mosquitoes, larvae and eggs.
 
And even dead ones pose a risk since Wolbachia can survive (at least) a week in a dead host — ample time for other organisms and creatures to acquire and spread it.

Many of these cases were diagnosed in the fall (which "fits" with the Culex spp. of mosquito acquiring Wolbachia in the spring and infecting humans in the fall). The WHO briefly acknowledged Culex as a Zika vector but quickly removed it.

 

 Supporting Study Quotes

 
"Nonimmune functions of the TLR family have been reported in Drosophila melanogaster in establishing the dorsal–ventral axis polarity, in synaptogenesis, and in axon pathfinding during embryogenesis (Anderson et al., 1985; Halfon et al., 1995; Rose et al., 1997). Such nonimmune functions of this receptor family have only recently emerged in mammals. We have recently shown that in the adult mammalian central nervous system (CNS), TLRs, including TLR4, regulate adult hippocampal neurogenesis (Rolls et al., 2007)."[5]
 
"The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4."[6]
 
"While cornea and conjunctiva express most of the TLRs, TLR4 is the lone TLR known to be expressed by uvea and sclera."[7]
 
"TLR4 mediated inflammation has also been associated with the aetiology of ocular onchocerciasis (popularly known as river blindness) which is a case of corneal inflammation with potential loss of vision. TLR4 has been implicated in the pathogenesis of several other ocular diseases ..."[7]
 
And, Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53:
 
"Like mammalian p53, Dmp53 binds specifically to human p53 binding sites, and overexpression of Dmp53 induces apoptosis."[8]
 
"In parallel studies of the p53 pathway, we found no evidence for p53 mutations but frequent disruption of the p53 pathway, such as overexpression of the p53 inhibitor HDM2."[9] 
 
"West Nile virus protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus."[10]
 
Zika shares the same phylogenetic clade alongside West Nile virus (even though the WHO and CDC constantly liken it to dengue and yellow fever).
 
 
I base that on pattern recognition of mass die-offs in vertebrates (Arctic terns, Roseate terns, North Atlantic right whales, Adelie penguins, other shorebirds, planktivorous fish, insectivores, and steelhead trout).
 
And because of the uptick in organic visits to a paper I wrote devoted to Zika in men (and the other 25 reference-based papers I've written on InfoBarrel). 
 
"One phage could potentially be used to modify a broad range of Wolbachia stains (Tanaka et al., 2009; Kent and Bordenstein, 2010; Wang et al., 2013)."[11]
 
"Rickettsial diseases are neglected, potentially severe, but easily treatable and preventable ... Sixteen of our participants with evidence of active rickettsial infection presented with a co-infection with an arbovirus."[12]
 

 

(Still Popular) Falsehoods

 
False: The uveal tract is normally devoid of any lymphatics in vertebrates.
 
Fact: A 2012 paper confirms: 
 
"Lymphangiogenesis plays important roles in ocular tumor progression. Yet, the role of lymphangiogenesis in most eye diseases, especially inflammatory disease or edema, remains unknown."[13] 
 
"The eye was thought to lack lymphatic vessels except for the conjunctiva; however, advances in the field, including the identification of lymphatic endothelial markers (e.g., LYVE-1 or podoplanin) and lymphangiogenic factors (e.g., VEGF-C), have revealed the exsitence and possible roles of lymphatics and lymphangiogenesis in the eye."[13]
 
False: Wolbachia isn’t harmful to humans.[14]
 
Fact: "The presence of Wolbachia lipoproteins found in these strains can exacerbate the human inflammation response and produce more severe disease symptoms." Source: Arthropod Borne Diseases by Carlos Brisola Marcondes (2016) pg. 618
 
"Wolbachia can come into contact with the mammalian immune system and acquire some of the characteristics of a bacterial pathogen. Moreover, Wolbachia has an intimate relationship with many arthropod vectors of vertebrate pathogens, such that it may have an indirect, but nevertheless very important, role to play in disease transmission." Source: Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development (2016) by Benjamin L. Makepeace and A. Christina Gill (2016) Chapter 21, pg. 465 
 
"Clearly, the bacteria [Wolbachia] are more virulent when they encounter a new species. However when the bacterial infection was closely examined, it was found that infected individuals of both species contained the same number of bacteria."[15]
 

Since 2003, it's been known Wolbachia can grow in

HUMAN lung cells (embryonic lung fibroblasts) at 37 C (98.6 F)

Culture and Phenotypic Characterization of a Wolbachia pipientis Isolate
Credit: Two sentences [Fair Use]

Feb. 11, 2018: The First Page of a Google Search Result

So, if "Wolbachia have never been found in humans [even though it has] or other mammals [North Atlantic right whales], birds, reptiles, or fish", then WHY IS NO ONE WILLING TO TEST FOR IT??

Wolbachia in mammals and humans Google search Feb 11, 2018
Credit: Page 1 Google Search Results of Wolbachia in Mammals and Humans [Fair Use]

In 1992 Scott O'Neill et al. Were Studying Wolbachia

Sequenced 16S rRNA Genes and Identified as a Proteobacteria (Most Closely Related to Rickettsia). They Knew How Powerful It Was in the Early 1990s:

16S rRNA phylogenetic analysis of the bacterial endosymbionts associated with cytoplasmic incompatibility in insects
Credit: Fair Use Portion of 16S rRNA phylogenetic analysis of the bacterial endosymbionts associated with cytoplasmic incompatibility in insects by Scott O'Neill et al. 1992

And how could 51 other research teams could be duped?

I think people have been "compensated" to keep facts hidden:

Immunology, Inflammation and Diseases of the Eye also

confirms Wolbachia DNA and intact Wolbachia are found in blood:

Immunology, Inflammation and Diseases of the Eye
Credit: Book: Immunology, Inflammation and Diseases of the Eye | Snippet from page 91 [Fair Use]

Risks of Wolbachia Mosquito Control (2016) AAAS

By Elgion Lucio Silva Loreto and Gabriel Luz Wallau

Risks of Wolbachia Mosquito Control by Elgion Lucio Silva Loreto and Gabriel Luz Wallau
Credit: Rose Webster (RoseWrites) [Fair Use]

Researchers continue to discover new species of Rickettsia Symptoms begin four to ten days after exposure and

include: fever, headache, rash, CNS changes, red eye, myalgias, arthralgias, hepatitis, vomiting, and cardiovascular instability (like the worst cases of Zika).

Rickettsial Diseases Book (2007) by Didier Raoult, Philippe Parola pg. 309
Credit: Four sentences from book [Fair Use]

Dr. Constancia Ayres warned the WHO Feb. 2016

Nov. 2016, Culex were briefly acknowledged but it was removed:

WHO briefly acknowledged Culex as a Zika vector but quickly removed it
Credit: Rose Webster (aka RoseWrites) [Fair Use]

Following the Science and Not the Hype

Dr. Fiona Hunter's Clade Shows Zika's Phylogenetics

Clade Fiona Hunter Used to Show Phylogenetic Placement of ZIKV
Credit: Rose Webster [Fair Use]

But Studies Comparing Zika to Hepatitis C and Others

are being funded. (We can wait a few years or test humans now).

Zika is not that related to Hep C
Credit: 2011 ICTV Placement of Viruses | Red circles and text added by Rose Webster [Fair Use]

How many eyeballs will be removed until 2021?

How many people will endure chemo? How many will die?

Rasgon project ends 2021
Credit: Rose Webster (RoseWrites on InfoBarrel) [Fair Use]

How could anyone predict "huge" profits for a rare cancer?

Unless, of course, they knew that many people would get it:

Intraocular Melanoma Treatment Market Progresses for Huge Profits During 2017 – 2025
Credit: Screenshot of title [Fair Use]

Where Wolbachia-Infected Aedes Have Been Released

Vs. Where Culex will acquire it and infect humans: pattern recognition

Correlation with Millions of Wolbachia-infected Aedes and uveal melanoma and lymphoma
Credit: Rose Webster (aka RoseWrites)

Addendum: April 15th, 2018

It certainly appears that men in Florida are becoming infected:

Rose Webster Google Analytics February to April 15 2018
Credit: Rose Webster's Google Analytics Results Feb to April 15, 2018

The War Against Zika: Fighting Mosquitoes With Mosquitoes

CBS Miami Report By Gary Nelson February 8, 2018 at 5:37 pm

The War Against Zika: Fighting Mosquitoes With Mosquitoes
Credit: Rose Webster [Fair Use]

It's FREE for Florida; the ROI in 3 - 6 years = $15 B

The $4.1 million program is being funded with a grant from the CDC

China’s Sperm Count Problem Has Created a Billion-Dollar Market
Credit: Rose Webster (aka RoseWrites) [Fair Use]

Global Distribution of Zika Vectors (Aedes & Culex)

Note: Culex tarsalis has been reported in West Africa too

Global Distribution Range of Zika Vectors
Credit: RoseWrites on InfoBarrel

Uveal Melanoma, UVR, p53, BDUMP, and Wolbachia-infected Aedes

Published: Jan. 14th, 2018 by Rose Webster

2003: Wolbachia can grow in human lung cells at 37 C

In 2015, it is found in a patient without the nematode (worm). The patient recovered fully once the Wolbachia infection was treated. He was cancer-free.

Wolbachia can grow at 37 C in human lung cells and in 2015 Wolbachia found in patient without worm
Credit: Fair Use Portions of Study Literature | Caricature of Author

Dr. Ahmed: 32,000 MDs Need Accurate Info From the AAO

Published Feb. 18, 2018

CDC Tells Health Professionals to Look For Adult Worms

Oh yeah, they invested $4.1 million into Wolbachia-infected Aedes releases in Florida which may become a $15 billion dollar ROI in a few years.

Gold Standard is Skin Snip according to CDC which only detects adult worms
Credit: Fair Use Portions of Google Search (Feb. 2018) and Study Result

Addendum March 31st, 2018: NEJM Confirms Mutations

In Either GNAQ or GNA11 = 83 Percent of Uveal Melanoma Cases

NEJM Mutations in GNA11 in Uveal Melanoma by Catherine D. Van Raamsdonk, Ph.D. et al. (2010)
Credit: Fair Use Portions of Mutations in GNA11 in Uveal Melanoma Paper and Wolbachia-Infected Mosquito Patent

Over 6 Years Later, 90 Percent of Mosquitoes Still Infected

Ergo, it will take decades to restore the ecological balance in some regions.

How will Wolbachia spread through the mosquito population? 90 percent still infected over 6 years later
Credit: Fair Use Portions of MosquitoMate's FAQ and 90 Percent Still Infected Over Six Years Later

I created a Change.org petition to help these patients

Uveal Melanoma or Lymphoma? R/O Rickettsiales (Wolbachia)

As stressed in my Change.org petition, Uveal Melanoma or Lymphoma? R/O Rickettsiales (Wolbachia):[17]

It is crucial that surgeons, eye care professionals, and oncologists utilize a broad range PCR screen for infection by Rickettsiales (Wolbachia genes detected in blood) before enucleation or evisceration.

Because there are treatment options for Wolbachia infections of the eye: doxycycline, minocycline, or rifampicin.[18] Rifampicin, also known as rifampin, is an antibiotic used to treat several types of bacterial infections, including tuberculosis, leprosy, and Legionnaire's disease.

And I understand that azithromycin can be used in combination with rifampin.[19]

This is a matter of life and death for some [many?] people.

About Change.org petitions: Anyone in the world can sign. You never need to donate money. 

How your signature helps: each time a supporter signs our petition, an email is automatically sent directly to those being petitioned (governments, companies and individuals). When hundreds or even thousands of emails arrive in their inboxes, our message is impossible to ignore.  
 

Recommended Reading and Other Ways to Help

On Zazzle, I have over 200 products to help promote awareness.

Uveal Melanoma and/or Lymphoma? R/O Rickettsiales (Wolbachia)

Zika: The Warnings About Wolbachia and Culex Our Health Authorities are Ignoring

Wolbachia-Infected Aedes: An Ill-Fated Experiment in French Polynesia

To help raise money for ethical Zika research and my documentary, I have designed 221 educational and/or humorous products on Zazzle for my Zika: Let's Stop a Global Pandemic Collection.[16]