Futurama is a well-known tv show that is actually pretty entertaining. Its a comedy thats set in the future, but it has some very sad and depressing episodes. These are the two most depressing there have been yet
In this episode the crew of Planet Express has to collect honey from a space bee hive. They nearly escape from the hive and they bring a baby bee on board. The bee stings through Fry and just pokes Leela. The episode show Leela slowly falling into depression and eating the honey to fall asleep because the only place she can see fry is in her dreams. She decides to drink the special honey that they go becuase if she drinks that she will fall asleep forever and get to stay with Fry. When she finally drinks it she wakes up and fry is there. She got all the poison from the bee and fell into a coma. Fry has been sitting there the entire time talking to her and keeping her company. The entire episode Leela was looking for Fry but he was there the entire time waiting for her to wake up.
Honorable Mention- Lethal Inspection
If you don't watch Futurama and are more into movies check out this movie review.